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Article

Molecular Regulation of the Polycomb Repressive-Deubiquitinase.

International journal of molecular sciences - 22 Oct 2020

Reddington Cameron J, Fellner Matthias, Burgess Abigail E, Mace Peter D

Abstract excerpt

Post-translational modification of histone proteins plays a major role in histone-DNA packaging and ultimately gene expression. Attachment of ubiquitin to the C-terminal tail of histone H2A (H2AK119Ub in mammals) is particularly relevant to the repression of gene transcription, and is removed by the Polycomb Repressive-Deubiquitinase (PR-DUB) complex. Here, we outline recent advances in the understanding of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33105797
DOI: 10.3390/ijms21217837
PMCID: PMC7660087

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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