Article

Three rules for epigenetic inheritance of human Polycomb silencing

2023-02-28

Abstract excerpt

Heritable expression of developmental genes is mediated by autoregulating transcription factor networks (TFNs) and Polycomb repressive chromatin silencing complexes (PRCs). Whether the mammalian Polycomb pathway mediates DNA sequence-independent epigenetic memory at genes being activated by TFNs remains unknown. Here, we show that, in human cells, newly induced Polycomb silencing at initially active developmental...

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Literature Corpus work: 47494dbc-8ac3-51aa-b06e-05e3b2831d06
DOI: 10.1101/2023.02.27.530239

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