Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

dBRWD3 Regulates Tissue Overgrowth and Ectopic Gene Expression Caused by Polycomb Group Mutations.

PLoS genetics - 1 Sept 2016

Shih Hsueh-Tzu, Chen Wei-Yu, Liu Kwei-Yan, Shih Zong-Siou, Chen Yi-Jyun, Hsieh Paul-Chen, Kuo Kuan-Lin, Huang Kuo-How, Hsu Pang-Hung, Liu Ya-Wen, Chan Shih-Peng, Lee Hsiu-Hsiang, Tsai Yu-Chen, Wu June-Tai

Abstract excerpt

To maintain a particular cell fate, a unique set of genes should be expressed while another set is repressed. One way to repress gene expression is through Polycomb group (PcG) proteins that compact chromatin into a silent configuration. In addition to cell fate maintenance, PcG proteins also maintain normal cell physiology, for example cell cycle. In the absence of PcG, ectopic activation of the PcG-repressed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Cycle
Share to Cell Cycle Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromatin

Share to Histone Chaperones

Share to Histones

Share to Imaginal Discs

Share to Polycomb-Group Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 27588417
DOI: 10.1371/journal.pgen.1006262
PMCID: PMC5010193

Genes

HIRA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

dBRWD3 Regulates Tissue Overgrowth and Ectopic Gene Expression Caused by Polycomb Group Mutations.PMID 27588417Read ↗

From genetics to epigenetics: the tale of Polycomb group and trithorax group genes.Semantic proximity Read ↗

Accessory subunits of PRC2 mimic H3K27me3 to restrict the spread of Polycomb domains.Semantic proximity Read ↗

Histone H2AK119 Mono-Ubiquitination is Essential for Polycomb-Mediated Transcriptional RepressionSemantic proximity Read ↗

BRD4 represses developmental and neuronal genes through interaction with PRC1.6Semantic proximity Read ↗

The mouse PcG gene eed is required for Hox gene repression and extraembryonic development.Semantic proximity Read ↗

Genomic context- and H2AK119 ubiquitination-dependent inheritance of human Polycomb silencing.Semantic proximity Read ↗

Epigenetic balance of gene expression by Polycomb and COMPASS families.Semantic proximity Read ↗

Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms.Semantic proximity Read ↗

Polycomb complexes in normal and malignant hematopoiesisSemantic proximity Read ↗

H2AK119ub Safeguards Against Ectopic Transcription Factor Mediated Gene Activation in the Developing ForebrainSemantic proximity Read ↗

The Polyhomeotic protein induces hyperplastic tissue overgrowth through the activation of the JAK/STAT pathway.Semantic proximity Read ↗

Molecular Regulation of the Polycomb Repressive-Deubiquitinase.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.