Article
Genome-wide association of multiple complex traits in outbred mice by ultra-low-coverage sequencing.
Nature genetics - 1 Aug 2016
Nicod Jérôme, Davies Robert W, Cai Na, Hassett Carl, Goodstadt Leo, Cosgrove Cormac, Yee Benjamin K, Lionikaite Vikte, McIntyre Rebecca E, Remme Carol Ann, Lodder Elisabeth M, Gregory Jennifer S, Hough Tertius, Joynson Russell, Phelps Hayley, Nell Barbara, Rowe Clare, Wood Joe, Walling Alison, Bopp Nasrin, Bhomra Amarjit, Hernandez-Pliego Polinka, Callebert Jacques, Aspden Richard M, Talbot Nick P, Robbins Peter A, Harrison Mark, Fray Martin, Launay Jean-Marie, Pinto Yigal M, Blizard David A, Bezzina Connie R, Adams David J, Franken Paul, Weaver Tom, Wells Sara, Brown Steve D M, Potter Paul K, Klenerman Paul, Lionikas Arimantas, Mott Richard, Flint Jonathan
Abstract excerpt
Two bottlenecks impeding the genetic analysis of complex traits in rodents are access to mapping populations able to deliver gene-level mapping resolution and the need for population-specific genotyping arrays and haplotype reference panels. Here we combine low-coverage (0.15×) sequencing with a new method to impute the ancestral haplotype space in 1,887 commercially available outbred mice. We mapped 156 unique...
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