Article
Fine mapping in 94 inbred mouse strains using a high-density haplotype resource.
Genetics - 1 Jul 2010
Kirby Andrew, Kang Hyun Min, Wade Claire M, Cotsapas Chris, Kostem Emrah, Han Buhm, Furlotte Nick, Kang Eun Yong, Rivas Manuel, Bogue Molly A, Frazer Kelly A, Johnson Frank M, Beilharz Erica J, Cox David R, Eskin Eleazar, Daly Mark J
Abstract excerpt
The genetics of phenotypic variation in inbred mice has for nearly a century provided a primary weapon in the medical research arsenal. A catalog of the genetic variation among inbred mouse strains, however, is required to enable powerful positional cloning and association techniques. A recent whole-genome resequencing study of 15 inbred mouse strains captured a significant fraction of the genetic variation among...
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