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Article

Trans-regulation of heterochromatin underlies genetic variation in 3D genome contacts in mouse embryonic stem cells.

Genome biology - 13 Jun 2026

Fortin Haley J, Struba Anna Z, Bustan Arad, Baker Christopher L

Abstract excerpt

BACKGROUND: Genetic variation drives phenotypic diversity and disease susceptibility. Trans-acting genetic variation coordinates genome-wide chromatin changes, yet the molecular mechanisms underlying this distal regulation remain unclear. Here, we use the power of mouse genetics to investigate how genetic variation at trans-acting loci regulates three-dimensional (3D) chromatin interactions. RESULTS: Using HiChIP...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42288869
DOI: 10.1186/s13059-026-04155-2
PMCID: PMC13501675

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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