Article

<i>Trans</i> -regulation of heterochromatin underlies genetic variation in 3D genome contacts

2025-12-12

Abstract excerpt

Genetic variation drives phenotypic diversity and disease susceptibility. Trans -acting genetic variation coordinates genome-wide chromatin changes, yet the molecular mechanisms underlying this regulation remain unclear. Here, we use the power of mouse genetics to investigate how genetic variation at trans -acting loci regulates 3D chromatin interactions. Using HiChIP to map H3K27ac-associated regulatory elemen...

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Literature Corpus work: ee6a8f55-5857-5527-be89-3341a1284e66
DOI: 10.64898/2025.12.10.693515

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