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CoCas9 is a compact nuclease from the human microbiome for efficient and precise genome editing

24 Apr 2024

Abstract excerpt

The expansion of the CRISPR-Cas toolbox is highly needed to accelerate the development of therapies for genetic diseases. Here, through the interrogation of a massively expanded repository of metagenome-assembled genomes, mostly from human microbiomes, we uncover a large variety (n = 17,173) of type II CRISPR-Cas loci. Among these we identify CoCas9, a strongly active and high-fidelity nuclease with reduced...

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PMID: 38658578
DOI: 10.1038/s41467-024-47800-9

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