Article

Compact type II-D Cas9 nucleases for efficient and specific genome editing

2026-08-18

Abstract excerpt

Compact CRISPR nucleases are attractive for therapeutic genome editing because their small coding sequences facilitate delivery by adeno-associated virus. Type II-D Cas9 (Cas9d) enzymes constitute the most compact Cas9 subtype, yet only a few orthologs have demonstrated mammalian genome-editing activity, leaving it unclear whether this activity is general or exceptional. Here, we mined the IMG/M metagenomic databa...

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Identifiers and source

Literature Corpus work: f22a856b-78a9-5757-8953-4288ab3a9816
DOI: 10.64898/2026.08.17.745286

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