Article

A deep learning and co-conservation framework enable discovery of non-canonical Cas proteins

2025-10-01

Abstract excerpt

CRISPR–Cas systems are central to prokaryotic adaptive immunity, widely harnessed for biotechnology. Yet, their vast and uncharacterized diversity, especially non-canonical variants, impedes full exploitation. Here we present BioPrinCRISPR, a class-agnostic computational framework leveraging gene co-conservation, protein domain co-occurrence, and embedding similarity to identify and characterize CRISPR–Cas systems...

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Literature Corpus work: c9f76fdd-7ff2-543f-a398-91e0680d6914
DOI: 10.1101/2025.09.30.679098

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