Article

Microengineered 3D pulmonary interstitial mimetics highlight a critical role for matrix degradation in idiopathic pulmonary fibrosis

2020-06-03

Abstract excerpt

Fibrosis is often untreatable and is characterized by aberrant tissue scarring from activated myofibroblasts. Although the extracellular matrix becomes increasingly stiff and fibrous during disease progression, how these physical cues impact myofibroblast differentiation in 3D is poorly understood. Here we describe a multicomponent hydrogel that recapitulates the 3D fibrous structure hallmark to the interstitial t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: deeec802-a45c-543e-b20c-aa0de0c31f53
DOI: 10.1101/2020.06.02.129718

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Microengineered 3D pulmonary interstitial mimetics highlight a critical role for matrix degradation in idiopathic pulmonary fibrosisDOI 10.1101/2020.06.02.129718Read

Dynamic hybrid-hydrogel lung models decouple matrix composition, stiffness, and fibroblast memory to define distinct drivers of fibrotic progressionSemantic proximity Read

Pulmonary Matrix Derived Hydrogels from Patients with Idiopathic Pulmonary Fibrosis Induce a Proinflammatory State in Lung Fibroblasts <i>In Vitro</i>Semantic proximity Read

Biomaterial-based 3D human lung models replicate pathological characteristics of early pulmonary fibrosisSemantic proximity Read

Destructive fibrotic teamwork: how both microenvironment stiffness and profibrotic interleukin 13 impair alveolar macrophage phenotype and function.Semantic proximity Read

Extracellular matrix as a driver of progressive fibrosisSemantic proximity Read

Matrix abnormalities in pulmonary fibrosis.Semantic proximity Read

Fibrotic human lung extracellular matrix as a disease-specific substrate for 3D <i>in-vitro</i> models of pulmonary fibrosisSemantic proximity Read

Hydrogel-Embedded Precision-Cut Lung Slices Recapitulate Fibrotic Gene Expression and Enable Therapeutic Response EvaluationSemantic proximity Read

Decoding mechanosensitive genes in cardiac fibroblasts via 3D hydrogel models of fibrosisSemantic proximity Read

Tenascin-C activation of lung fibroblasts in a 3D synthetic lung extracellular matrix mimicSemantic proximity Read

Progressive matrix stiffening of tyramine-modified silk fibroin hydrogels governs stage-specific pulmonary fibroblast activationSemantic proximity Read

Engineered 3D environments reprogram fibroblast-mediated inflammation in rheumatoid ArthritisSemantic proximity Read