Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Abatacept increases T cell exhaustion in early RA individuals who carry HLA risk alleles.

Frontiers in immunology - 1 Jan 2024

Long Sarah Alice, Muir Virginia S, Jones Britta E, Wall Valerie Z, Ylescupidez Alyssa, Hocking Anne M, Pribitzer Stephan, Thorpe Jerill, Fuchs Bryce, Wiedeman Alice E, Tatum Megan, Lambert Katharina, Uchtenhagen Hannes, Speake Cate, Ng Bernard, Heubeck Alexander T, Torgerson Troy R, Savage Adam K, Maldonado Michael A, Ray Neelanjana, Khaychuk Vadim, Liu Jinqi, Linsley Peter S, Buckner Jane H

Abstract excerpt

Exhausted CD8 T cells (TEX) are associated with worse outcome in cancer yet better outcome in autoimmunity. Building on our past findings of increased TIGIT+KLRG1+ TEX with teplizumab therapy in type 1 diabetes (T1D), in the absence of treatment we found that the frequency of TIGIT+KLRG1+ TEX is stable within an individual but differs across individuals in both T1D and healthy control (HC) cohorts. This...

Topics

Join the communities discussing this publication.

Abatacept
Alleles
Antirheumatic Agents
Arthritis, Rheumatoid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

CD8-Positive T-Lymphocytes

Lectins, C-Type

Receptors, Immunologic

Source

Open in PubMed Open full text

Identifiers

PMID: 38650930
DOI: 10.3389/fimmu.2024.1383110
PMCID: PMC11033422

Genes

KLRG1
TIGIT
EOMES

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Abatacept increases T cell exhaustion in early RA individuals who carry HLA risk alleles.PMID 38650930Read ↗

CD8 T Cell Exhaustion During Chronic Viral Infection and CancerSemantic proximity Read ↗

Autoantigen-specific CD4+ T cells acquire an exhausted phenotype and persist in human antigen-specific autoimmune diseases.Semantic proximity Read ↗

Costimulatory blockade depletes T peripheral helper, late-activated naïve, and DN2 B cells in rheumatoid arthritisSemantic proximity Read ↗

T cell exhaustion dynamics in systemic autoimmune diseaseSemantic proximity Read ↗

Peripheral T cell populations are differentially affected in monogenic autoinflammatory syndromes and goutSemantic proximity Read ↗

Tonic-signaling chimeric antigen receptors drive human regulatory T cell exhaustionSemantic proximity Read ↗

Deep immunophenotyping reveals circulating activated lymphocytes in individuals at risk for rheumatoid arthritisSemantic proximity Read ↗

Multi-centered T cell repertoire profiling identifies novel alterations in the immune repertoire of individuals with inflammatory bowel disease and validates previous findingsSemantic proximity Read ↗

Regulation of gene expression in autoimmune disease loci and the genetic basis of proliferation in CD4+ effector memory T cells.Semantic proximity Read ↗

Trib1 regulates T cell differentiation during chronic infection by restraining the effector program.Semantic proximity Read ↗

CTLA4 protects against maladaptive cytotoxicity during differentiation of effector and follicular CD4+ T cellsSemantic proximity Read ↗

Inflammatory arthritis immune related adverse events represent a unique autoimmune disease entity primarily driven by T cells, but likely not autoantibodiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.