Article
Trib1 regulates T cell differentiation during chronic infection by restraining the effector program.
The Journal of experimental medicine - 4 May 2020
Rome Kelly S, Stein Sarah J, Kurachi Makoto, Petrovic Jelena, Schwartz Gregory W, Mack Ethan A, Uljon Sacha, Wu Winona W, DeHart Anne G, McClory Susan E, Xu Lanwei, Gimotty Phyllis A, Blacklow Stephen C, Faryabi Robert B, Wherry E John, Jordan Martha S, Pear Warren S
Abstract excerpt
In chronic infections, the immune response fails to control virus, leading to persistent antigen stimulation and the progressive development of T cell exhaustion. T cell effector differentiation is poorly understood in the context of exhaustion, but targeting effector programs may provide new strategies for reinvigorating T cell function. We identified Tribbles pseudokinase 1 (Trib1) as a central regulator of...
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