Article
Specificity, frequency, and phenotype of citrullinated-specific T cells vary with disease activity in rheumatoid arthritis.
JCI insight - 8 Sept 2026
Rims Cliff, DeBerg Hannah A, Posso Sylvia E, Muir Virginia S, Uchtenhagen Hannes, Hocking Anne M, Bukiri Heather, Carlin Jeffrey, Ng Bernard, Linsley Peter S, James Eddie A, Buckner Jane H
Abstract excerpt
In rheumatoid arthritis (RA), CD4+ T cells specific for citrullinated antigens (cit-antigens) are key drivers of disease, but knowledge about epitopes and phenotypes remains limited. We characterized the frequency and phenotype of cit-specific CD4+ T cells in peripheral blood using HLA class II tetramers combined with computational analysis of phenotypic clusters to simultaneously detect peptides derived from 5...
Read the complete abstract on PubMedTopics
- Humans
- Arthritis, Rheumatoid
- Female
- Male
- Middle Aged
- CD4-Positive T-Lymphocytes