Article
Autoantigen-specific CD4+ T cells acquire an exhausted phenotype and persist in human antigen-specific autoimmune diseases.
Immunity - 8 Oct 2024
Saggau Carina, Bacher Petra, Esser Daniela, Rasa Mahdi, Meise Silja, Mohr Nicola, Kohlstedt Nora, Hutloff Andreas, Schacht Sarah-Sophie, Dargvainiene Justina, Martini Gabriela Rios, Stürner Klarissa H, Schröder Ina, Markewitz Robert, Hartl Johannes, Hastermann Maria, Duchow Ankelien, Schindler Patrick, Becker Mareike, Bautista Carolin, Gottfreund Judith, Walter Jörn, Polansky Julia K, Yang Mingxing, Naghavian Reza, Wendorff Mareike, Schuster Ev-Marie, Dahl Andreas, Petzold Andreas, Reinhardt Susanne, Franke Andre, Wieczorek Marek, Henschel Lea, Berger Daniel, Heine Guido, Holtsche Maike, Häußler Vivien, Peters Christian, Schmidt Enno, Fillatreau Simon, Busch Dirk H, Wandinger Klaus-Peter, Schober Kilian, Martin Roland, Paul Friedemann, Leypoldt Frank, Scheffold Alexander
Abstract excerpt
Pro-inflammatory autoantigen-specific CD4+ T helper (auto-Th) cells are central orchestrators of autoimmune diseases (AIDs). We aimed to characterize these cells in human AIDs with defined autoantigens by combining human leukocyte antigen (HLA)-tetramer-based and activation-based multidimensional ex vivo analyses. In aquaporin4-antibody-positive neuromyelitis optica spectrum disorder (AQP4-NMOSD) patients,...
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