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Article

T cell exhaustion dynamics in systemic autoimmune disease

2023-12-23

Abstract excerpt

Unlike in infection and cancer, T cell exhaustion in autoimmune disease has not been clearly defined. Here we set out to understand inhibitory protein (PD-1, Tim3, CTLA4, Lag3) expression in CXCR5- and CXCR5+ CD8 and CD4 T cells in systemic lupus erythematosus. CXCR5+ CD8 and CD4 T cells express PD-1 and engage B cells in germinal center reactions, leading to autoantibody formation in autoimmunity. We hypothesized...

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Identifiers and source

Literature Corpus work
e7da700a-8886-577e-a50c-b4e881202171
DOI
10.1101/2023.12.23.573167
Open publication

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T cell exhaustion dynamics in systemic autoimmune diseaseDOI 10.1101/2023.12.23.573167
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