Article

Costimulatory blockade depletes T peripheral helper, late-activated naïve, and DN2 B cells in rheumatoid arthritis

2026-03-16

Abstract excerpt

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that causes joint destruction along with extra-articular morbidity and early mortality. Abatacept (CTLA-4 Ig), a blocker of lymphocyte co-stimulation, has become a well-accepted biologic treatment with proven efficacy in established-RA and for preventing disease onset in predisposed individuals. To investigate the immunologic implications of ab...

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Literature Corpus work: 11c734fa-afb7-5fbb-99ee-44aa77647627
DOI: 10.64898/2026.03.14.26348386

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