Article

Inflammatory arthritis immune related adverse events represent a unique autoimmune disease entity primarily driven by T cells, but likely not autoantibodies

2025-06-06

Abstract excerpt

<h4>ABSTRACT</h4> Immune checkpoint inhibitor (ICI)–induced inflammatory arthritis (IA) is an increasingly recognized immune-related adverse event (irAE), yet its underlying immunopathogenesis remains poorly understood. Unlike rheumatoid arthritis (RA), where autoantibodies and B cell dysfunction are central features, the contribution of humoral immunity to IA irAE is unclear. Here, we performed in-depth immunoph...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e3d305f1-65a3-553f-8148-171ff9b185d8
DOI: 10.1101/2025.06.06.25328991

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Inflammatory arthritis immune related adverse events represent a unique autoimmune disease entity primarily driven by T cells, but likely not autoantibodiesDOI 10.1101/2025.06.06.25328991Read

Bridging clinical phenotypes with molecular mechanisms in autoimmune irAEs: An Etiopathogenic framework.Semantic proximity Read

Clonally expanded CD38 hi cytotoxic CD8 T cells define the T cell infiltrate in checkpoint inhibitor–associated arthritisSemantic proximity Read

An NKG2A biased immune response confers protection for infection, autoimmune disease, and cancerSemantic proximity Read

Costimulatory blockade depletes T peripheral helper, late-activated naïve, and DN2 B cells in rheumatoid arthritisSemantic proximity Read

Preexisting autoimmune disease is a risk factor for immune-related adverse events: a meta-analysisSemantic proximity Read

Autoimmune disorders.Semantic proximity Read

Clonally expanded CD38 <sup>hi</sup> cytotoxic CD8 T cells define the T cell infiltrate in checkpoint inhibitor-associated arthritisSemantic proximity Read

CD8(+) T cells in human autoimmune arthritis: the unusual suspects.Semantic proximity Read

T cell and autoantibody profiling for primary immune regulatory disordersSemantic proximity Read

Autoimmune disease: genetic susceptibility, environmental triggers, and immune dysregulation. Where can we develop therapies?Semantic proximity Read

Research progress on mechanisms and predictive biomarkers for immune-related adverse eventsSemantic proximity Read

Cutting Edge: Molecular Portrait of Human Autoimmune DiseaseSemantic proximity Read