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Article

Single-mitosis dissection of acute and chronic DNA mutagenesis and repair.

Nature genetics - 1 May 2024

Ginno Paul Adrian, Borgers Helena, Ernst Christina, Schneider Anja, Behm Mikaela, Aitken Sarah J, Taylor Martin S, Odom Duncan T

Abstract excerpt

How chronic mutational processes and punctuated bursts of DNA damage drive evolution of the cancer genome is poorly understood. Here, we demonstrate a strategy to disentangle and quantify distinct mechanisms underlying genome evolution in single cells, during single mitoses and at single-strand resolution. To distinguish between chronic (reactive oxygen species (ROS)) and acute (ultraviolet light (UV))...

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Identifiers

PMID: 38627597
DOI: 10.1038/s41588-024-01712-y
PMCID: PMC11096113

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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