Pervasive lesion segregation shapes cancer genome evolution.

doi:10.1038/s41586-020-2435-1

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Article

Pervasive lesion segregation shapes cancer genome evolution.

Nature - 1 Jul 2020

Aitken Sarah J, Anderson Craig J, Connor Frances, Pich Oriol, Sundaram Vasavi, Feig Christine, Rayner Tim F, Lukk Margus, Aitken Stuart, Luft Juliet, Kentepozidou Elissavet, Arnedo-Pac Claudia, Beentjes Sjoerd V, Davies Susan E, Drews Ruben M, Ewing Ailith, Kaiser Vera B, Khamseh Ava, López-Arribillaga Erika, Redmond Aisling M, Santoyo-Lopez Javier, Sentís Inés, Talmane Lana, Yates Andrew D, Semple Colin A, López-Bigas Núria, Flicek Paul, Odom Duncan T, Taylor Martin S

Abstract excerpt

Cancers arise through the acquisition of oncogenic mutations and grow by clonal expansion1,2. Here we reveal that most mutagenic DNA lesions are not resolved into a mutated DNA base pair within a single cell cycle. Instead, DNA lesions segregate, unrepaired, into daughter cells for multiple cell generations, resulting in the chromosome-scale phasing of subsequent mutations. We characterize this process in...

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Identifiers

PMID: 32581361
DOI: 10.1038/s41586-020-2435-1
PMCID: PMC7116693

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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