Article
Strand-resolved mutagenicity of DNA damage and repair.
Nature - 1 Jun 2024
Anderson Craig J, Talmane Lana, Luft Juliet, Connelly John, Nicholson Michael D, Verburg Jan C, Pich Oriol, Campbell Susan, Giaisi Marco, Wei Pei-Chi, Sundaram Vasavi, Connor Frances, Ginno Paul A, Sasaki Takayo, Gilbert David M, López-Bigas Núria, Semple Colin A, Odom Duncan T, Aitken Sarah J, Taylor Martin S
Abstract excerpt
DNA base damage is a major source of oncogenic mutations1. Such damage can produce strand-phased mutation patterns and multiallelic variation through the process of lesion segregation2. Here we exploited these properties to reveal how strand-asymmetric processes, such as replication and transcription, shape DNA damage and repair. Despite distinct mechanisms of leading and lagging strand replication3,4, we observe...
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