Article
Comprehensive Analysis of Hypermutation in Human Cancer.
Cell - 16 Nov 2017
Campbell Brittany B, Light Nicholas, Fabrizio David, Zatzman Matthew, Fuligni Fabio, de Borja Richard, Davidson Scott, Edwards Melissa, Elvin Julia A, Hodel Karl P, Zahurancik Walter J, Suo Zucai, Lipman Tatiana, Wimmer Katharina, Kratz Christian P, Bowers Daniel C, Laetsch Theodore W, Dunn Gavin P, Johanns Tanner M, Grimmer Matthew R, Smirnov Ivan V, Larouche Valérie, Samuel David, Bronsema Annika, Osborn Michael, Stearns Duncan, Raman Pichai, Cole Kristina A, Storm Phillip B, Yalon Michal, Opocher Enrico, Mason Gary, Thomas Gregory A, Sabel Magnus, George Ben, Ziegler David S, Lindhorst Scott, Issai Vanan Magimairajan, Constantini Shlomi, Toledano Helen, Elhasid Ronit, Farah Roula, Dvir Rina, Dirks Peter, Huang Annie, Galati Melissa A, Chung Jiil, Ramaswamy Vijay, Irwin Meredith S, Aronson Melyssa, Durno Carol, Taylor Michael D, Rechavi Gideon, Maris John M, Bouffet Eric, Hawkins Cynthia, Costello Joseph F, Meyn M Stephen, Pursell Zachary F, Malkin David, Tabori Uri, Shlien Adam
Abstract excerpt
We present an extensive assessment of mutation burden through sequencing analysis of >81,000 tumors from pediatric and adult patients, including tumors with hypermutation caused by chemotherapy, carcinogens, or germline alterations. Hypermutation was detected in tumor types not previously associated with high mutation burden. Replication repair deficiency was a major contributing factor. We uncovered new driver...
Topics
- Adult
- Child
- Cluster Analysis
- DNA Polymerase II