Article

Cancer mutational processes vary in their association with replication timing and chromatin accessibility

2021-05-05

Abstract excerpt

<h4>Background</h4> Cancer somatic mutations are the product of multiple mutational and repair processes, which are tightly associated with DNA replication. Distinctive patterns of somatic mutations accumulation in tumors, termed mutational signatures, are indicative of processes the tumors underwent. While tumor mutational load is correlated with late replicating regions and spatial genome organization, much is...

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Literature Corpus work: a2486879-91f4-5bb8-bdc6-ba009c3be33f
DOI: 10.1101/2021.05.05.442736

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