Article

Topographical archetypes of somatic mutagenesis in cancer

2026-04-21

Abstract excerpt

The genome of every cancer cell carries a record of the mutational processes that have acted throughout its history. Mutational signature analysis, which infers the activity of mutagenic processes from their characteristic base-change patterns, has become an indispensable tool for interpreting somatic mutations. However, this framework captures only which types of mutations a process generates and not where in the...

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Literature Corpus work: dcd39c98-696b-5a05-894a-2bdcb7062ad0
DOI: 10.64898/2026.04.18.719374

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