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Article

Clock-like mutational signatures: Linking ageing to endogenous cancer risk.

Ageing research reviews - 1 Jun 2026

Mills Charlie, Niedzwiedz Wojciech, Houlston Richard S

Abstract excerpt

Clock-like mutational signatures, principally the single base substitution signatures SBS1 and SBS5, with smaller contributions from SBS18 and SBS40, accumulate approximately linearly with chronological age across nearly all normal human somatic tissues. Initially viewed as simple molecular odometers of lifetime cell divisions, these signatures are now recognised to reflect a far more complex interplay of...

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PMID: 42031320
DOI: 10.1016/j.arr.2026.103147

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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