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Article

Tissue-specific enhancer-gene maps from multimodal single-cell data identify causal disease alleles.

Nature genetics - 1 Apr 2024

Sakaue Saori, Weinand Kathryn, Isaac Shakson, Dey Kushal K, Jagadeesh Karthik, Kanai Masahiro, Watts Gerald F M, Zhu Zhu, Brenner Michael B, McDavid Andrew, Donlin Laura T, Wei Kevin, Price Alkes L, Raychaudhuri Soumya

Abstract excerpt

Translating genome-wide association study (GWAS) loci into causal variants and genes requires accurate cell-type-specific enhancer-gene maps from disease-relevant tissues. Building enhancer-gene maps is essential but challenging with current experimental methods in primary human tissues. Here we developed a nonparametric statistical method, SCENT (single-cell enhancer target gene mapping), that models association...

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Identifiers

PMID: 38594305
DOI: 10.1038/s41588-024-01682-1
PMCID: PMC11456345

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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