Article

ECLIPSER: identifying causal cell types and genes for complex traits through single cell enrichment of e/sQTL-mapped genes in GWAS loci

2021-11-25

Abstract excerpt

<h4>Summary</h4> ECLIPSER was developed to identify pathogenic cell types and cell type-specific genes that may affect complex disease susceptibility and trait variation by integrating single cell data with known GWAS loci. ECLIPSER maps genes to GWAS loci for a given complex trait based on expression and splicing quantitative trait loci (e/sQTLs) and other functional data, and tests whether the mapped genes are...

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Literature Corpus work: bc01829d-e578-5671-ac29-28c6ccee03e2
DOI: 10.1101/2021.11.24.469720

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