Article

Single-cell multiome regression models identify functional and disease-associated enhancers and enable chromatin potential analysis

2023-06-14

Abstract excerpt

We present a novel gene-level regulatory model called SCARlink that predicts single-cell gene expression from single-cell chromatin accessibility within and flanking (+/-250kb) the genic loci by training on multiome (scRNA-seq and scATAC-seq co-assay) sequencing data. The approach uses regularized Poisson regression on tile-level accessibility data to jointly model all regulatory effects at a gene locus, avoiding...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c85e05dd-abfa-5603-b023-ee49ce138037
DOI: 10.1101/2023.06.13.544851

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single-cell multiome regression models identify functional and disease-associated enhancers and enable chromatin potential analysisDOI 10.1101/2023.06.13.544851Read

Tissue-specific enhancer-gene maps from multimodal single-cell data identify causal disease allelesSemantic proximity Read

Tissue-specific enhancer-gene maps from multimodal single-cell data identify causal disease alleles.Semantic proximity Read

SCENIC+: single-cell multiomic inference of enhancers and gene regulatory networksSemantic proximity Read

scRiskDB: a single-cell epigenomic resource linking complex traits to regulatory mechanisms across human tissues.Semantic proximity Read

Mapping enhancer-gene regulatory interactions from single-cell dataSemantic proximity Read

A single-cell atlas of transcribed <i>cis</i> -regulatory elements in the human genomeSemantic proximity Read

UniversalEPI: robust prediction of cell type-specific and differential chromatin interactions from DNA sequence and chromatin accessibilitySemantic proximity Read

Predicting cell type-specific epigenomic profiles accounting for distal genetic effects.Semantic proximity Read

A sequence-based global map of regulatory activity for deciphering human geneticsSemantic proximity Read

Airqtl dissects cell state-specific causal gene regulatory networks with efficient single-cell eQTL mappingSemantic proximity Read

Optimising expression quantitative trait locus mapping workflows for single-cell studiesSemantic proximity Read

Expression QTLs in single-cell sequencing dataSemantic proximity Read