Article

Population-scale skeletal muscle single-nucleus multi-omic profiling reveals extensive context specific genetic regulation

2023-12-15

Abstract excerpt

Skeletal muscle, the largest human organ by weight, is relevant in several polygenic metabolic traits and diseases including type 2 diabetes (T2D). Identifying genetic mechanisms underlying these traits requires pinpointing cell types, regulatory elements, target genes, and causal variants. Here, we use genetic multiplexing to generate population-scale single nucleus (sn) chromatin accessibility (snATAC-seq) and t...

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Literature Corpus work: 977211b3-4ebf-5d9b-9d9b-9c7bc3c775fc
DOI: 10.1101/2023.12.15.571696

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