Article
Cryo-EM structures of RAD51 assembled on nucleosomes containing a DSB site.
Nature - 1 Apr 2024
Shioi Takuro, Hatazawa Suguru, Oya Eriko, Hosoya Noriko, Kobayashi Wataru, Ogasawara Mitsuo, Kobayashi Takehiko, Takizawa Yoshimasa, Kurumizaka Hitoshi
Abstract excerpt
RAD51 is the central eukaryotic recombinase required for meiotic recombination and mitotic repair of double-strand DNA breaks (DSBs)1,2. However, the mechanism by which RAD51 functions at DSB sites in chromatin has remained elusive. Here we report the cryo-electron microscopy structures of human RAD51-nucleosome complexes, in which RAD51 forms ring and filament conformations. In the ring forms, the N-terminal...
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