Article

Structural mechanism of strand exchange by the RAD51 filament

2025-03-26

Abstract excerpt

<h4>SUMMARY</h4> Homologous Recombination (HR) preserves genomic stability by repairing double-strand DNA breaks and ensuring efficient DNA replication. Central to HR is the strand-exchange reaction taking place within the three-stranded synapsis wherein a RAD51 nucleoprotein filament binds to a donor DNA. Here we present the cryoEM structure of a displacement loop of human RAD51 that captures the synaptic state...

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Literature Corpus work: 0b89bf1d-7b91-5ff6-99ea-4b772a8f33fc
DOI: 10.1101/2025.03.26.645421

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