Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Structural basis of nucleosome remodeling by Cockayne syndrome B homologue Komagataella phaffii Rad26.

Nature communications - 24 Jun 2026

Fukushima Yutaro, Kinoshita Chiaki, Negishi Lumi, Kujirai Tomoya, Kobayashi Yuki, Ogasawara Mitsuo, Ehara Haruhiko, Sekine Shun-Ichi, Kagawa Wataru, Kurumizaka Hitoshi, Takizawa Yoshimasa

Abstract excerpt

Rad26, a yeast homologue of mammalian Cockayne syndrome protein B (CSB), plays an essential role in transcription-coupled nucleotide excision repair (TC-NER). Rad26/CSB binds RNA polymerase II stalled at DNA lesions and recruits DNA repair factors, functioning as a molecular scaffold. In addition, Rad26/CSB possesses nucleosome-remodeling activity that may help restore transcription after DNA repair. Here we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Triphosphatases
Share to Chromatin Assembly and Disassembly

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cryoelectron Microscopy

Share to DNA Helicases

Share to DNA Repair

Share to DNA Repair Enzymes

Share to Nucleosomes

Share to Poly-ADP-Ribose Binding Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 42342665
DOI: 10.1038/s41467-026-73500-7
PMCID: PMC13294370

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Structural basis of nucleosome remodeling by Cockayne syndrome B homologue Komagataella phaffii Rad26.PMID 42342665Read ↗

Elf1 promotes Rad26’s interaction with lesion-arrested Pol II for transcription-coupled repairSemantic proximity Read ↗

Mechanistic insights into the regulation of transcription and transcription-coupled DNA repair by Cockayne syndrome protein B.Semantic proximity Read ↗

Cockayne syndrome B protein acts as an ATP-dependent processivity factor that helps RNA polymerase II overcome nucleosome barriers.Semantic proximity Read ↗

Structure and function of the RAD51B–RAD51C–RAD51D–XRCC2 tumour suppressorSemantic proximity Read ↗

Regulation of active genome integrity and expression by Rad26p.Semantic proximity Read ↗

ATP-Dependent Chromatin Remodeler CSB Couples DNA Repair Pathways to Transcription with Implications for Cockayne Syndrome and Cancer TherapySemantic proximity Read ↗

Cryo-EM structures of RAD51 assembled on nucleosomes containing a DSB site.Semantic proximity Read ↗

Novel structural insights on full-length human RAD52: Cryo-EM and beyondSemantic proximity Read ↗

Every protagonist has a sidekick: Structural aspects of human xeroderma pigmentosum-binding proteins in nucleotide excision repair.Semantic proximity Read ↗

Structure of the human Bre1 complex bound to the nucleosomeSemantic proximity Read ↗

Mechanism of Rad26-assisted rescue of stalled RNA polymerase II in transcription-coupled repair.Semantic proximity Read ↗

Mre11–Rad50–Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin templateThis paper is one of a selection of papers published in this Special Issue, entitled 28th International West Coast Chromatin and Chromosome Conference, and has undergone the Journal's usual peer review process.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.