Article

Principles of subclonal gene dosage across human cancer

2026-03-18

Abstract excerpt

Intratumor heterogeneity drives disease progression, but even though subclonal copy number variation (CNV) is a major contributor to this heterogeneity 1 , its impact on cell phenotype is not fully understood. Here, by applying high-quality joint whole genome sequencing and mRNA profiling in single cells (DNTR-seq 2 ) to solid tumors and leukemias from 57 patients, we have analyzed the in vivo transcriptional e...

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Literature Corpus work: ca5c911e-5d45-5e66-8e89-bc50b8b89911
DOI: 10.64898/2026.03.15.711906

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