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Article

α-catenin middle- and actin-binding domain unfolding mutants differentially impact epithelial strength and sheet migration.

Molecular biology of the cell - 1 May 2024

Quinn Jeanne M, Wang Yuou, Wood Megan, Flozak Annette S, Le Phuong M, Yemelyanov Alex, Oakes Patrick W, Gottardi Cara J

Abstract excerpt

α-catenin (α-cat) displays force-dependent unfolding and binding to actin filaments through direct and indirect means, but features of adherens junction structure and function most vulnerable to loss of these allosteric mechanisms have not been directly compared. By reconstituting an α-cat F-actin-binding domain unfolding mutant known to exhibit enhanced binding to actin (α-cat-H0-FABD+) into α-cat knockout Madin...

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Share to Actin Cytoskeleton
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38507238
DOI: 10.1091/mbc.E23-01-0036
PMCID: PMC11151094

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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