Article
Sorting of cadherin-catenin-associated proteins into individual clusters.
Proceedings of the National Academy of Sciences of the United States of America - 20 Jul 2021
Troyanovsky Regina B, Sergeeva Alina P, Indra Indrajyoti, Chen Chi-Shuo, Kato Rei, Shapiro Lawrence, Honig Barry, Troyanovsky Sergey M
Abstract excerpt
The cytoplasmic tails of classical cadherins form a multiprotein cadherin-catenin complex (CCC) that constitutes the major structural unit of adherens junctions (AJs). The CCC in AJs forms junctional clusters, "E clusters," driven by cis and trans interactions in the cadherin ectodomain and stabilized by α-catenin-actin interactions. Additional proteins are known to bind to the cytoplasmic region of the CCC....
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