Article

α-catenin mechanosensitivity as a route to cytokinesis failure through sequestration of LZTS2

2023-08-26

Abstract excerpt

<h4>ABSTRACT</h4> Epithelial cells can become polyploid upon tissue injury, but mechanosensitive cues that trigger this state are poorly understood. Using α-catenin (α-cat) knock-out Madin Darby Canine Kidney (MDCK) cells reconstituted with wild-type and mutant forms of α-cat as a model system, we find that an established α-cat actin-binding domain unfolding mutant designed to reduce force-sensitive binding to F-...

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Literature Corpus work: ab2b68d0-1e49-542b-8c02-eee3974a8864
DOI: 10.1101/2023.08.25.554884

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