Article
α-Catenin force-sensitive binding and sequestration of LZTS2 leads to cytokinesis failure.
The Journal of cell biology - 3 Mar 2025
Wang Yuou, Yemelyanov Alex, Go Christopher D, Kim Sun K, Quinn Jeanne M, Flozak Annette S, Le Phuong M, Liang Shannon, Gingras Anne-Claude, Ikura Mitsu, Ishiyama Noboru, Gottardi Cara J
Abstract excerpt
Epithelial cells can become polyploid upon tissue injury, but mechanosensitive cues that trigger this state are poorly understood. Using an Madin Darby Canine Kidney (MDCK) cell knock-out/reconstitution system, we show that α-catenin mutants that alter force-sensitive binding to F-actin or middle (M)-domain promote cytokinesis failure and binucleation, particularly near epithelial wound-fronts. We identified...
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