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Article

Disease-associated mutant alpha-actinin-4 reveals a mechanism for regulating its F-actin-binding affinity.

Proceedings of the National Academy of Sciences of the United States of America - 9 Oct 2007

Weins Astrid, Schlondorff Johannes S, Nakamura Fumihiko, Denker Bradley M, Hartwig John H, Stossel Thomas P, Pollak Martin R

Abstract excerpt

Alpha-actinin-4 is a widely expressed protein that employs an actin-binding site with two calponin homology domains to crosslink actin filaments (F-actin) in a Ca(2+)-sensitive manner in vitro. An inherited, late-onset form of kidney failure is caused by point mutations in the alpha-actinin-4 actin-binding domain. Here we show that alpha-actinin-4/F-actin aggregates, observed in vivo in podocytes of humans and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17901210
DOI: 10.1073/pnas.0702451104
PMCID: PMC2042165

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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