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Article

Force-dependent vinculin binding of α-catenin accelerates adherens junction formation.

Cell structure and function - 1 Jan 2026

Gan Quan, Tsukita Sachiko, Yonemura Shigenobu

Abstract excerpt

Adherens junctions (AJs) mediate cell-cell adhesion and mechanical coupling in epithelial tissues. During AJ formation, punctate AJs (punctum adherens; PA) initially appear and subsequently transition into linear AJs or zonula adherens (ZAs). The mechanosensitive interaction of α-catenin with its binding partners-actin filaments and vinculin-is thought to act as a key switch that stabilizes AJs under tension....

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Identifiers

PMID: 41656095
DOI: 10.1247/csf.25140

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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