Article

Molecular basis of proteolytic cleavage regulation by the extracellular matrix receptor dystroglycan

2022-04-04

Abstract excerpt

<h4>ABSTRACT</h4> The dystrophin glycoprotein complex (DGC), anchored by the transmembrane protein dystroglycan, functions to mechanically link the extracellular matrix to the actin cytoskeleton to drive critical aspects of development and adult homeostasis. Breaking this connection via mutation of the actin adaptor protein dystrophin or impaired glycosylation of dystroglycan are strongly associated with diseases...

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Literature Corpus work: d06bbec4-d8eb-5677-af85-3f78cf7b0ff1
DOI: 10.1101/2022.04.04.487063

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