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Article

Expression of α-synuclein is regulated in a neuronal cell type-dependent manner

25 Oct 2018

Abstract excerpt

α-Synuclein, the major component of Lewy bodies (LBs) and Lewy neurites (LNs), is expressed in presynapses under physiologically normal conditions and is involved in synaptic function. Abnormal intracellular aggregates of misfolded α-synuclein such as LBs and LNs are pathological hallmarks of synucleinopathies, including Parkinson's disease (PD) and dementia with Lewy bodies (DLB). According to previous studies...

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PMID: 30362073
DOI: 10.1007/s12565-018-0464-8

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