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Article

Novel AAV-based rat model of forebrain synucleinopathy shows extensive pathologies and progressive loss of cholinergic interneurons.

PloS one - 1 Jan 2014

Aldrin-Kirk Patrick, Davidsson Marcus, Holmqvist Staffan, Li Jia-Yi, Björklund Tomas

Abstract excerpt

Synucleinopathies, characterized by intracellular aggregation of α-synuclein protein, share a number of features in pathology and disease progression. However, the vulnerable cell population differs significantly between the disorders, despite being caused by the same protein. While the vulnerability of dopamine cells in the substantia nigra to α-synuclein over-expression, and its link to Parkinson's disease, is...

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Identifiers

PMID: 24999658
DOI: 10.1371/journal.pone.0100869
PMCID: PMC4085060

Genes

SNCA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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