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Article

Structure/function of α‐synuclein in health and disease: rational development of animal models for Parkinson's and related diseases

24 Jul 2002

Abstract excerpt

α-Synuclein (αSYN) was originally identified in the electric organ of the electric eel Torpedo californica ( Maroteaux et al. 1988 ). It is now well documented that αSYN and its close homolog βSYN are abundantly expressed in presynaptic terminals of vertebrates. Experimental down-regulation of αSYN in knock-out mice and in primary neurones suggests that αSYN regulates synaptic neurotransmission, but the molecular...

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PMID: 12153470
DOI: 10.1046/j.1471-4159.2002.01020.x

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