Article

Alpha-Synuclein in Neurodegeneration: From Shared Biology to Disease-Specific Phenotypes

2026-02-11

Abstract excerpt

Alpha-synuclein (αSyn) is one of the most abundant proteins in the nervous system and is currently associated with devastating synucleinopathies, yet its biology extends far beyond this. In this review, we outline a unified model suggesting that αSyn‑driven disease emerges within specific neural circuits through the combined effects of cell‑type‑specific roles, subcellular environments, and post‑translational modi...

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Literature Corpus work: 08d82f09-1856-5d1a-9db0-3c1461b34489
DOI: 10.20944/preprints202602.0860.v1

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