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Article

Integrative cross-omics and cross-context analysis elucidates molecular links underlying genetic effects on complex traits.

Nature communications - 16 Mar 2024

Lu Yihao, Oliva Meritxell, Pierce Brandon L, Liu Jin, Chen Lin S

Abstract excerpt

Genetic effects on functionally related 'omic' traits often co-occur in relevant cellular contexts, such as tissues. Motivated by the multi-tissue methylation quantitative trait loci (mQTLs) and expression QTLs (eQTLs) analysis, we propose X-ING (Cross-INtegrative Genomics) for cross-omics and cross-context integrative analysis. X-ING takes as input multiple matrices of association statistics, each obtained from...

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Identifiers

PMID: 38493154
DOI: 10.1038/s41467-024-46675-0
PMCID: PMC10944527

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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