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An integrative multi-context Mendelian randomization method for identifying risk genes across human tissues

2024-03-07

Abstract excerpt

Mendelian randomization (MR) provides valuable assessments of the causal effect of exposure on outcome, yet the application of conventional MR methods for mapping risk genes encounters new challenges. One of the issues is the limited availability of expression quantitative trait loci (eQTLs) as instrumental variables (IVs), hampering the estimation of sparse causal effects. Additionally, the often context/tissue-s...

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Literature Corpus work
84a41fc1-9a23-57cc-872a-2e6fac4398ac
DOI
10.1101/2024.03.04.24303731
Open publication

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An integrative multi-context Mendelian randomization method for identifying risk genes across human tissuesDOI 10.1101/2024.03.04.24303731
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