Article

Partitioning and aggregating cross-tissue and tissue-specific genetic effects in identifying gene-trait associations

2023-12-12

Abstract excerpt

<title>Abstract</title> <p>Transcriptome-wide association studies (TWAS) have shown great promises in extending GWAS loci to a functional understanding of disease mechanisms. In an effort to fully unleash the TWAS and GWAS information, we propose MTWAS, a statistical framework that partitions and aggregates cross-tissue and tissue-specific genetic effects in identifying gene-trait associations. Different from pre...

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Literature Corpus work: 760e6aec-e24a-56ac-ab6d-33b3c7444eeb
DOI: 10.21203/rs.3.rs-3674156/v1

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