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Leveraging genome-wide effects on gene expression to identify disease-critical genes with <i>trans</i> -genetic components

2026-02-25

Abstract excerpt

Genome-wide association studies (GWAS) have implicated tens of thousands of genetic variants associated with complex traits and polygenic diseases. Colocalizing GWAS variants with variants that may regulate gene expression, via expression quantitative trait loci (eQTL) mapping, has successfully led to the identification of disease-critical genes and their cell types of action. Recent studies predominantly colocali...

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Literature Corpus work
8fc6e13e-762b-579c-b3ed-1f074eb37dba
DOI
10.64898/2026.02.23.26346922
Open publication

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Leveraging genome-wide effects on gene expression to identify disease-critical genes with <i>trans</i> -genetic componentsDOI 10.64898/2026.02.23.26346922
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