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Article

An integrative multi-context Mendelian randomization method for identifying risk genes across human tissues.

American journal of human genetics - 8 Aug 2024

Lu Yihao, Xu Ke, Maydanchik Nathaniel, Kang Bowei, Pierce Brandon L, Yang Fan, Chen Lin S

Abstract excerpt

Mendelian randomization (MR) provides valuable assessments of the causal effect of exposure on outcome, yet the application of conventional MR methods for mapping risk genes encounters new challenges. One of the issues is the limited availability of expression quantitative trait loci (eQTLs) as instrumental variables (IVs), hampering the estimation of sparse causal effects. Additionally, the often context- or...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39053459
DOI: 10.1016/j.ajhg.2024.06.012
PMCID: PMC11339623

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