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Article

DNA methylation QTL mapping across diverse human tissues provides molecular links between genetic variation and complex traits.

Nature genetics - 1 Jan 2023

Oliva Meritxell, Demanelis Kathryn, Lu Yihao, Chernoff Meytal, Jasmine Farzana, Ahsan Habibul, Kibriya Muhammad G, Chen Lin S, Pierce Brandon L

Abstract excerpt

Studies of DNA methylation (DNAm) in solid human tissues are relatively scarce; tissue-specific characterization of DNAm is needed to understand its role in gene regulation and its relevance to complex traits. We generated array-based DNAm profiles for 987 human samples from the Genotype-Tissue Expression (GTEx) project, representing 9 tissue types and 424 subjects. We characterized methylome and transcriptome...

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Source

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Identifiers

PMID: 36510025
DOI: 10.1038/s41588-022-01248-z
PMCID: PMC10249665

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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